A meta-analysis to correlate lead bioavailability and bioaccessibility and predict lead bioavailability
نویسندگان
چکیده
منابع مشابه
A meta-analysis to correlate lead bioavailability and bioaccessibility and predict lead bioavailability.
Defining the precise clean-up goals for lead (Pb) contaminated sites requires site-specific information on relative bioavailability data (RBA). While in vivo measurement is reliable but resource insensitive, in vitro approaches promise to provide high-throughput RBA predictions. One challenge on using in vitro bioaccessibility (BAc) to predict in vivo RBA is how to minimize the heterogeneities ...
متن کاملLead bioaccessibility in 12 contaminated soils from China: Correlation to lead relative bioavailability and lead in different fractions.
This study investigated the relationship between Pb relative bioavailability (RBA) and bioaccessibility, and their relationships with Pb in different pools in soils. Twelve Pb-contaminated soils representing different contamination sources from China were analyzed for Pb bioaccessibility using four in vitro methods (UBM, SBRC, IVG, and PBET), Pb-RBA using a mouse blood model, and Pb fractionati...
متن کاملExperimental determination of the oral bioavailability and bioaccessibility of lead particles
In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposur...
متن کاملRoles of lead-binding proteins in mediating lead bioavailability.
The intracellular bioavailability of lead (Pb) at low dosage levels in major target organs such as the kidney and brain appears to be largely determined by complexation with a group of low molecular weight proteins. These proteins are rich in aspartic and glutamic dicarboxyl amino acids. The proteins are chemically similar but not identical across all species examined to date and the brain prot...
متن کاملLycopene bioaccessibility and bioavailability from processed foods
Lycopene is one of the most abundant caroteinoids naturally occurring in red fruits and vegetables, especially tomato and its derivatives. It has potent antioxidant activity and can reduce risk of certain chronic diseases and cancers. A key limitation of lycopene use is that its intestinal absorption is far to be complete and highly variable depending on food processing. Consuming fat markedly ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environment International
سال: 2016
ISSN: 0160-4120
DOI: 10.1016/j.envint.2016.04.009